Synthesis of a library of indolizines using poly (ethylene glycol) as soluble support

Z Chen, G Yue, C Lu, G Yang

Index: Chen, Zuxing; Yue, Guizhou; Lu, Cuifen; Yang, Guichun Synlett, 2004 , # 7 p. 1231 - 1234

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Citation Number: 30

Abstract

Abstract A library of indolizines has been synthesized using poly (ethylene glycol)(PEG) as soluble polymer support. The PEG-supported pyridinium ylide reacted with alkenes or alkynes to give PEG-bound indolizines. Cleavage from the soluble polymer support was induced by KCN/MeOH to afford the indolizines. This synthetic method is simple, the reaction conditions are mild and the yields are high to excellent.