Synthesis, Analgesic and Antiinflammatory properties of Certain 5??/6??Acyl??3??(4??substituted??1??piperazinylmethyl)??2??benzoxazolinones Derivatives

…, N Goekhan, E Kuepeli, E Yesilada…

Index: Koeksal, Meric; Goekhan, Nesrin; Kuepeli, Esra; Yesilada, Erdem; Erdogan, Hakki Archiv der Pharmazie, 2005 , vol. 338, # 2-3 p. 117 - 125

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Citation Number: 5

Abstract

Abstract The synthesis of a novel series of Mannich bases of 5-/6-acyl-5-methyl-2- benzoxazolinones has been described. The structures attributed to compounds 2a, 3a, 4a, 4b, 9a, 9b, 5a–5g, 6a–6g, 10a, 10g, 11a, 11g have been elucidated using IR and 1 H NMR spectroscopic techniques besides elemental analysis. The compounds have been evaluated for their in vivo analgesic and antiinflammatory activities using the p- ...