New Reagent for Convenient Access to the α, β??Unsaturated N??Methoxy??N??methyl??amide Functionality by a Synthesis Based on the Julia Olefination Protocol

B Narayana Manjunath, NP Sane…

Index: Manjunath, Beedimane Narayana; Sane, Neeraj P.; Aidhen, Indrapal Singh European Journal of Organic Chemistry, 2006 , # 12 p. 2851 - 2855

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Citation Number: 15

Abstract

Abstract A new reagent for the synthesis of the α, β-unsaturated N-methoxy-N-methyl-amide structural unit has been developed. 2-(Benzo [d] thiazol-2-ylsulfonyl)-N-methoxy-N- methylacetamide, a crystalline solid with an indefinite shelf life that can be easily prepared in two convenient steps from 2-chloro-N-methoxy-N-methylacetamide, reacted with a variety of aldehydes under Julia conditions to furnish the α, β-unsaturated N-methoxy-N-methyl- ...