Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogs

…, IM Uwaydah, WJ Welstead Jr, LF Sancilio…

Index: Walsh; Moran; Shamblee; Uwaydah; Welstead Jr.; Sancilio; Dannenburg Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1379 - 1388

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Citation Number: 71

Abstract

A series of substituted derivatives of 2-amino-3-benzoylphenylacetic acid (amfenac) has been synthesized and evaluated for antiinflammatory, analgesic, and cyclooxygenase inhibiting activity. Several derivatives including 157 (4/-ChlOrO), 158 (4'-bromo), and 182 (5- chloro, 4'-bromo) were more potent than indomethacin in these assays.