Selective fluorescent chemosensor for the bacterial alarmone (p) ppGpp

…, MR Song, M Cashel, HE Choy, YJ Seok…

Index: Rhee, Hyun-Woo; Lee, Chang-Ro; Cho, Seung-Hyon; Song, Mi-Ryung; Cashel, Michael; Choy, Hyon E.; Seok, Young-Jae; Hong, Jong-In Journal of the American Chemical Society, 2008 , vol. 130, # 3 p. 784 - 785

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Citation Number: 69

Abstract

We have developed the first selective fluorescent chemosensor (PyDPA) for (p) ppGpp, a bacterial and plant alarmone. By using pyrene-excimer fluorescence, PyDPA shows very good selectivity for (p) ppGpp from among other nucleotides in water. PyDPA was used for the real-time detection of in vitro ppGpp synthesis by bacterial ribosomal complexes.

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