Cyclopropyl??tryptamine Analogues: Synthesis and Biological Evaluation as 5??HT6 Receptor Ligands

…, J Szymoniak, F Fabis, S Butt??Gueulle, S Rault…

Index: Szalata, Claude; Szymoniak, Jan; Fabis, Frederic; Butt-Gueulle, Sabrina; Rault, Sylvain; Bertus, Philippe; Gerard, Stephane; Sapi, Janos ChemMedChem, 2013 , vol. 8, # 1 p. 70 - 73

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Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that produces its effects via interaction with 5-HT receptors and serotonin the transporter (SERT). At least seven distinct serotonin receptor subclasses are expressed in the mammalian central nervous system (CNS).[1] Among these families, 5-HT6 is the most recently discovered and cloned member. Rat and mouse 5-HT6 receptors were described in 1993 and 1994, ...