Journal of the American Chemical Society

Catalytic Enantioselective Allylic Amination of Unactivated Terminal Olefins via an Ene Reaction/[2, 3]-Rearrangement

H Bao, UK Tambar

Index: Bao, Hongli; Tambar, Uttam K. Journal of the American Chemical Society, 2012 , vol. 134, # 45 p. 18495 - 18498

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Citation Number: 26

Abstract

The enantioselective allylic amination of unactivated terminal olefins represents a direct and attractive strategy for the synthesis of enantioenriched amines. We have developed the first use of a nitrogen-containing reagent and a chiral palladium catalyst to convert unfunctionalized olefins into enantioenriched allylic amines via an ene reaction/[2, 3]- rearrangement.

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