Synthesis of Annulated Pyridines by Intramolecular Inverse??Electron??Demand Hetero??Diels–Alder Reaction under Superheated Continuous Flow Conditions

RE Martin, F Morawitz, C Kuratli…

Index: Martin, Rainer E.; Morawitz, Falk; Kuratli, Christoph; Alker, Andre M.; Alanine, Alexander I. European Journal of Organic Chemistry, 2012 , # 1 p. 47 - 52

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Citation Number: 12

Abstract

Abstract Pyrimidine alkynes can be transformed into the corresponding annulated pyridines efficiently in flow. The superheating of organic solvents far beyond their boiling point enables toxic and difficult to workup solvents such as nitrobenzene or chlorobenzene, which are usually employed for these reactions, to be replaced by less harmful ones like toluene. The relative rate of reactivity for a series of structurally close starting materials was ...