Bioorganic & medicinal chemistry

Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site

A Viger, PB Dervan

Index: Viger, Anne; Dervan, Peter B. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8539 - 8549

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Citation Number: 32

Abstract

The vascular endothelial growth factor (VEGF) and its receptors have been implicated as key-factors in tumor angiogenesis and are major targets in cancer therapy. New oligomers which mimic the architecture of DNA-binding polyamides have been designed to target the hypoxia inducible factor (HIF-1α) binding site on the promoter of VEGF gene. These oligomers incorporate an increasing number of six–five fused rings such as ...