Chemistry Letters

TOTAL SYNTHESIS OF (±)-AKLAVINONE VIA BIOMIMETIC ROUTE. APPLICATION OF AN EFFICIENT “ZIPPER” REACTION—STEREOCONTROLLED ONE-STEP …

K Maruyama, H Uno, Y Naruta

Index: Maruyama, Kazuhiro; Uno, Hidemitsu; Naruta, Yoshinori Chemistry Letters, 1983 , p. 1767 - 1770

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Citation Number: 2

Abstract

(±)-Aklavinone (1) was synthesized from tricarbonylnaphthalene derivative 6 by application of an efficient “zipper” reaction in a good yield. Using Kryptofix 222 (4, 7, 13, 16, 21, 24- hexaoxa-1, 10-diazabicyclo [8.8. 8] hexacosane) in the key process of the reaction we attained a stereocontrolled one-step bicyclo-cyclization.