Synthesis of 1-amino-1-(aminomethyl) cyclopropane and its monobenzamides

F Vergne, DJ Aitken, HP Husson

Index: Vergne, Fabrice; Aitken, David J.; Husson, Henri-Philippe Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 6071 - 6075

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Citation Number: 17

Abstract

An increasing number of therapeutic agents, including antiarrythmic, antipsychotic, and antitumor compounds, have structures which incorporate a 1, f-diamine function. As an extension of our program'dealing with the preparation of cyclopropane compounds of biological interest? we required a method for the synthesis of a series of 1, 2- diaminoethanes in which one of the carbon atoms is incorporated into a cyclopropane ring ...