Tetrahedron

Synthesis of 2, 5-diaryloxazoles through friedel-crafts reaction of azlactones with aromatic hydrocarbons

PT Frangopol, AT Balaban, L Bǎrlǎdeanu…

Index: Frangopol,P.T. et al. Tetrahedron, 1961 , vol. 16, p. 59 - 67

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Citation Number: 13

Abstract

2-Phenyl-5-oxazolone (hippuric acid azlactone, I) gives good yields of benzoylamino- ketones (II) in the Friedel-Crafts benzoylaminoacetylation of aromatic hydrocarbons. On this basis a new synthesis of 2, 5-diaryloxazoles was devised, resulting in the simplest preparation of several 2-phenyl-5-aryl-oxazoles (III), which are good scintillator solutes. Ultra- violet absorption spectra are described and discussed.