The Journal of Organic Chemistry

Kinetics and mechanism of the reaction of ketones with lithium reagents in cyclohexane

MA Al-Aseer, SG Smith

Index: Al-Aseer, Munther A.; Smith, Stanley G. Journal of Organic Chemistry, 1984 , vol. 49, # 14 p. 2608 - 2613

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Citation Number: 32

Abstract

The kinetics of the reaction of sec-BuLi and n-BuLi with several substituted phenyl sec-butyl ketones in cyclohexane at 25.0 OC have been examined by stopped-flow infrared spectroscopy. Experiments in which reacting solutions of the ketones were scanned over the carbonyl region of the infrared spectrum revealed the presence of an intermediate which was characterized as a reversibly formed complex between ketone and alkyllithium ...