Synthesis, cytostatic and trichomonacide activities of 3, 5-bis-(halomethyl) pyrazoles

…, P Navarro, MI Rodríguez-Franco, M Contreras…

Index: Iturrino; Navarro; Rodriguez-Franco; Contreras; Escario; Martinez; Del Rosario Pardo European Journal of Medicinal Chemistry, 1987 , vol. 22, # 5 p. 445 - 451

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Citation Number: 21

Abstract

Abstract Reduction of 1-methyl-and 1-benzyl-diethylpyrazole-3, 5-dicarboxylates 2a and 2b with diisobutylaluminium hydride in toluene gave 3, 5-bis-(hydroxymethyl) pyrazoles 4a and 4b in very good yields. Alternatively, 4a was obtained by reduction of S, S-diethyl 1- methylpyrazole-3, 5-dicarbothioate 3 ″with lithium aluminium hydride in lower yield. Treatment of above diols 4a and 4b with thionyl chloride or phosphorous tribromide in ...