Reductive amination products containing naphthalene and indole moieties bind to melanocortin receptors

F Mutulis, I Mutule, M Lapins, JES Wikberg

Index: Mutulis, Felikss; Mutule, Ilze; Lapins, Maris; Wikberg, Jarl E.S. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1035 - 1038

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Citation Number: 27

Abstract

Presumed pharmacophoric groups of melanocortin peptides (naphthalene, amino or guanidine, and indole moieties) were combined in mimetics molecules looking for their favorable location for activity at melanocortin (MC) receptors. Twenty-two compounds were prepared and tested. The best of these displayed micromolar affinities for the MC receptors.

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[Ding, Xiao; Li, Yan; Lv, Li; Zhou, Mi; Han, Li; Zhang, Zhengxi; Ba, Qian; Li, Jingquan; Wang, Hui; Liu, Hong; Wang, Renxiao ChemMedChem, 2013 , vol. 8, # 12 p. 1986 - 2014]

Reductive amination products containing naphthalene and indole moieties bind to melanocortin receptors

Abstract

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