Inactivation of medium-chain acyl-CoA dehydrogenase by a metabolite of hypoglycin: characterization of the major turnover product and evidence suggesting an …

MT Lai, D Li, E Oh, HW Liu

Index: Lai, Ming-tain; Li, Ding; Oh, Eugene; Liu, Hung-wen Journal of the American Chemical Society, 1993 , vol. 115, # 5 p. 1619 - 1628

Full Text: HTML

Citation Number: 71

Abstract

Abstract: Medium-chain acyl-CoA dehydrogenase (MCAD) is a FAD-dependent enzyme that catalyzes the first step of the fatty acid oxidation cycle. When MCAD is exposed to ( methylenecyclopropy1) acetyl-CoA (MCPA-CoA), a metabolite of hypoglycin A and the causative agent of Jamaican vomiting sickness, time-dependent inactivation follows with concomitant bleaching of the active-site FAD. Earlier studies have led to the postulation ...

Related Articles:

Synthesis of dienoic acids and esters by cationic palladium complex catalyzed carbonylation of alkynols and alkynediols

[Huh, Keun-Tae; Orita, Akihiro; Alper, Howard Journal of Organic Chemistry, 1993 , vol. 58, # 25 p. 6956 - 6957]

Synthesis of 3, 6-dihydro-2H-pyran-2-ones via cationic palladium (II) complex-catalyzed tandem [2+ 2] cycloaddition-allylic rearrangement of ketene with α, β- …

[Hattori, Tetsutaro; Suzuki, Yutaka; Ito, Yuuichi; Hotta, Daido; Miyano, Sotaro Tetrahedron, 2002 , vol. 58, # 26 p. 5215 - 5223]

Preparation of esters of 4-alkyl-2, 4-pentadienoic acids by the phosphonate modification of the Wittig reaction

[Sundberg,R.J. et al. Journal of Organic Chemistry, 1967 , vol. 32, p. 2938 - 2941]

More Articles...