Bioorganic & medicinal chemistry

Chemical model studies on the monoamine oxidase-B catalyzed oxidation of 4-substituted 1-methyl-1, 2, 3, 6-tetrahydropyridines

C Franot, S Mabic, N Castagnoli

Index: Franot, Christelle; Mabic, Stephane; Castagnoli Jr., Neal Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1519 - 1529

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Citation Number: 7

Abstract

The MAO-B catalyzed α-carbon oxidation of amines has been proposed to proceed via either a single electron transfer (SET) or hydrogen atom transfer (HAT) pathway. In an attempt to distinguish between these pathways, we have examined the α-carbon oxidation of a series of 4-substituted 1-methyl-1, 2, 3, 6-tetrahydropyridine derivatives, compounds which are MAO-B substrates, employing chemical models of the SET pathway [using the PF6− ...