2, 4??Dioxa??7??aza??, 2, 4??Dioxa??8??aza??, and 2, 4??Dioxa??9??aza??3??phosphadecalins as Rigid Acetylcholine Mimetics: Syntheses and Characterization

…, W Ganci, F Gorla, U Ringeisen, P RüEDI

Index: Furegati, Stefan; Ganci, Walter; Gorla, Fabrizio; Ringeisen, Urs; Rueedi, Peter Helvetica Chimica Acta, 2004 , vol. 87, # 10 p. 2629 - 2661

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Citation Number: 20

Abstract

Abstract Phosphorylation of suitable piperidine precursors yielded a series of novel decalin- type O, N, P-heterocycles. The title compounds, P (3)-axially and P (3)-equatorially X- substituted, cis-and trans-configurated 2, 4-dioxa-7-aza-, 2, 4-dioxa-8-aza-, and 2, 4-dioxa-9- aza-3-phosphabicyclo [4.4. 0] decane 3-oxides (X= Cl, F, 4-nitrophenoxy, and 2, 4- dinitrophenoxy), are configuratively fixed and conformationally constrained P-analogues ...