Synthesis of 7β-phenylacetamido-6-oxo-2-oxabicyclo [3.2. 0] heptane-4α-carboxylic acid, a cyclobutanone analogue of a β-lactam antibiotic

G Lowe, S Swain

Index: Lowe, Gordon; Swain, Steven Journal of the Chemical Society, Chemical Communications, 1983 , # 22 p. 1279 - 1281

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Citation Number: 8

Abstract

A route has been developed for the synthesis of cyclobutanone analogues of p-lactam antibiotics. ... The p-lactam antibiotics constitute the most important class ... Although the search for new microbial p-lactam antibiotics ... Published on 01 January 1983. Downloaded by google on 19/02/2016 01:39:00. ... View Article Online / Journal Homepage / Table of Contents for this issue ... Scheme 1. Reagents: i, Na-liq. NH,-Me,CHOH then PhCH,Br-K,CO,- ...