An Easy Access to 4, 5-Disubstituted Thiazoles via Base-Induced Click Reaction of Active Methylene Isocyanides with Methyl Dithiocarboxylates

GS Lingaraju, TR Swaroop, AC Vinayaka…

Index: Lingaraju, Gejjalagere S.; Swaroop, Toreshettahally R.; Vinayaka, Ajjampura C.; Sharath Kumar, Kothanahally S.; Sadashiva, Marilinganadoddi P.; Rangappa, Kanchugarakoppal S. Synthesis, 2012 , vol. 44, # 9 p. 1373 - 1379

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Citation Number: 20

Abstract

Abstract An efficient synthesis of 4, 5-disubstituted thiazoles via base-induced cyclization of active methylene isocyanides such as tosylmethyl isocyanide, ethyl isocyanoacetate, and arylmethyl isocyanides with methyl arene-and hetarenecarbodithioates is reported. This synthesis could be a new click chemistry reaction, since it is simple, rapid, and often avoids purification steps. In addition, this method allow us a clear and general synthesis of novel ...