Enantioselective synthesis of β-hydroxy amines and aziridines using asymmetric transfer hydrogenation of α-amino ketones

AM Kawamoto, M Wills

Index: Kawamoto; Wills Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 16 p. 1916 - 1928

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Citation Number: 37

Abstract

Aziridines are valuable synthetic reagents and intermediates. In particular they benefit from high reactivity due to the small, strained, nitrogen-containing rings, thus permitting their rapid conversion into a range of derivatives. The synthesis of enantiomerically pure aziridines is a desirable objective since the physiological properties of both the aziridines themselves and the products formed from them are likely to be dependent on the absolute configuration. 1