2-Arylindenes and 2-arylindenones. Synthesis of probes to study the binding orientation of unsymmetrical nonsteroidal ligands to the estrogen receptor

…, CS Peterson, JA Katzenellenbogen

Index: Anstead; Ensign; Peterson; Katzenellenbogen Journal of Organic Chemistry, 1989 , vol. 54, # 7 p. 1485 - 1491

Full Text: HTML

Citation Number: 39

Abstract

A set of 2-arylindene and-indenone systems, bearing a 3-ethyl or 3-aryl substituent and a single hydroxyl group either on the 6-position of the indene or 4'-position of the C-2 aryl group, have been synthesized in connection with a larger investigation of the orientation with which 2-arylindene nonsteroidal estrogens bind to the estrogen receptor. The 6- hydroxyl-substituted systems are prepared by a-benzylation or benzoylation of a benzyl ...

Related Articles:

Synthesis of indenones via palladium-catalyzed annulation of internal alkynes

[Larock, R. C.; Doty, M. J.; Cacchi, S. Journal of Organic Chemistry, 1993 , vol. 58, # 17 p. 4579 - 4583]

Synthesis of indenones via palladium-catalyzed annulation of internal alkynes

[Larock, R. C.; Doty, M. J.; Cacchi, S. Journal of Organic Chemistry, 1993 , vol. 58, # 17 p. 4579 - 4583]

Synthesis of indenones via palladium-catalyzed annulation of internal alkynes

[Larock, R. C.; Doty, M. J.; Cacchi, S. Journal of Organic Chemistry, 1993 , vol. 58, # 17 p. 4579 - 4583]

Sigmatropic rearrangements of 1, 1-diarylindenes. Migratory aptitudes of aryl migration in the ground and electronically excited states

[Manning, Carl; McClory, Michael R.; McCullough, John J. Journal of Organic Chemistry, 1981 , vol. 46, # 5 p. 919 - 930]

Sigmatropic rearrangements of 1, 1-diarylindenes. Migratory aptitudes of aryl migration in the ground and electronically excited states

[Manning, Carl; McClory, Michael R.; McCullough, John J. Journal of Organic Chemistry, 1981 , vol. 46, # 5 p. 919 - 930]

More Articles...