Triplex-forming ability of oligonucleotides containing 1-aryl-1, 2, 3-triazole nucleobases linked via a two atom-length spacer

Y Hari, M Nakahara, S Obika

Index: Hari, Yoshiyuki; Nakahara, Motoi; Obika, Satoshi Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5583 - 5588

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Abstract

Abstract Phosphoramidites containing 2-propynyloxy or 1-butyn-4-yl as nucleobase precursors were synthesized and introduced into oligonucleotides using an automated DNA synthesizer. Copper-catalyzed alkyne-azide 1, 3-dipolar cycloaddition of the oligonucleotides with various azides gave the corresponding triazolylated oligonucleotides, triplex-forming ability of these synthetic oligonucleotides with double-stranded DNA ...