Journal of the American Chemical Society

8-Amino-2, 4-Dimethylquinoline1

WR Vaughan

Index: Vaughan Journal of the American Chemical Society, 1948 , vol. 70, p. 2294

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Citation Number: 2

Abstract

As a consequence of the tremendous recent interest in the derivatives of 8-aminoquinoline as antimalarial drugs it was found desirable to develop a satisfactory synthesis for 8-amino- 2, 4-dimethylquinoline. The present procedure was found to be a rapid and efficient method for the preparation of this substance, one of its advantages being that it obviates any extensive purification of the intermediate 8-nitro-2, 4-dimethylquinoline.