Synthesis and in vitro characterization of some benzothiazole-and benzofuranone-derivatives for quantification of fibrillar aggregates and inhibition of amyloid- …

SA Ghadami, Z Hossein-pour, R Khodarahmi…

Index: Ghadami, Seyyed Abolghasem; Hossein-Pour, Zahra; Khodarahmi, Reza; Ghobadi, Sirous; Adibi, Hadi Medicinal Chemistry Research, 2013 , vol. 22, # 1 p. 115 - 126

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Abstract

Abstract Neurodegenerative diseases are characterized by amyloid deposition. Thioflavin T (ThT) is one of the molecules considered for detection of amyloid deposits; however, its lipophilicity is too low to cross the blood–brain barrier. Therefore, there is a strong motivation to develop suitable compounds for in vitro fibril quantification as well as for in vivo amyloid imaging. Moreover, oxidative stress (particularly, uncontrolled peroxidase activity) has ...

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