Bioorganic & medicinal chemistry

A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells

M Koh, JC Lee, C Min, A Moon

Index: Koh, Minsoo; Lee, Jong-Cheol; Min, Changhee; Moon, Aree Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 8 p. 2305 - 2313

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Citation Number: 25

Abstract

Mounting evidence suggests that metformin (N, N-dimethylbiguanide), a widely prescribed drug for the treatment of type II diabetes, exerts an anti-tumor effect on several cancers including breast cancer. Breast cancer has been estimated as one of the most commonly diagnosed types of cancer among women. In particular, triple-negative breast cancers are associated with poor prognosis and metastatic growth. In the present study, we ...