Potential antiatherosclerotic agents. 2.(Aralkylamino)-and (alkylamino) benzoic acid analogs of cetaben

…, SA Schaffer, RG Shepherd, J Upeslacis

Index: Albright; DeVries; Largis; Miner; Reich; Schaffer; Shepherd; Upeslacis Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1378 - 1393

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Citation Number: 23

Abstract

The syntheses of a series of (aralky1amino)-and (alky1amino) benzoic acids, as well as the corresponding esters and sodium salts, are described. The compounds were evaluated in vivo in rats for serum sterol and triglyceride lowering activity and in vitro for activity in inhibiting the principle cholesterol-esterifying enzyme of the arterial wall, fatty acyl-CoA: cholesterol acyltransferase (ACAT). Based on a combination of these two activities, ...