Radiosynthesis and in vivo evaluation of a F??18??labeled pancreatic islet amyloid inhibitor
G Pathuri, HB Agashe, V Awasthi…
Index: Pathuri, Gopal; Agashe, Hrushikesh B.; Awasthi, Vibhudutta; Gali, Hariprasad Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 4 p. 186 - 191
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Abstract
Abstract Formation of islet amyloid deposits contributes to the progressive loss of beta-cells in Type 2 diabetes. Islet amyloid is composed of islet amyloid polypeptide (IAPP).[(N-Me) G 24,(N-Me) I 26] hIAPP (22–27) peptide was found to bind human IAPP with high-affinity and inhibit fibrillogenesis. We labeled [(N-Me) G 24,(N-Me) I 26] hIAPP (22–27) with fluorine-18 using N-succinimidyl-4-[18 F] fluorobenzoate. Results from biodistribution studies in ...
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