Bioorganic & medicinal chemistry

Triarylethylene bisphenols with a novel cycle are ligands for the estrogen receptor

SH Kim, JA Katzenellenbogen

Index: Kim, Sung-Hoon; Katzenellenbogen, John A. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 4 p. 785 - 793

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Citation Number: 26

Abstract

We have prepared a series of triarylethylene and triarylethane systems, analogues of the selective antiestrogen tamoxifen, in which the alkyl substituent is tethered to the distal, rather than the proximal aryl ring by a 5-, 6-, or 7-membered carbocycle. This unusual cyclic