Efficient synthesis and resolution of novel 2-(hydroxymethyl)-7, 8-dihydro-1H-indeno [5, 4-b] furan-6 (2H)-one by lipase Pseudomonas cepacia

L Nagarapu, HR Vulupala, R Bantu, Y Sajja…

Index: Nagarapu, Lingaiah; Vulupala, Hanmanth Reddy; Bantu, Rajashaker; Sajja, Yashodakrishna; Nanubolu, Jagadeesh Babu Tetrahedron Asymmetry, 2014 , vol. 25, # 6-7 p. 578 - 582

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Citation Number: 4

Abstract

Abstract Lipase Pseudomonas cepacia catalyzed acylation of (±)-2-(hydroxymethyl)-7, 8- dihydro-1H-indeno [5, 4-b] furan-6 (2H)-one using vinyl acetate as the acyl donor in acetone gave (−)-(R)-2-acetoxy-2-(methyl)-7, 8-dihydro-1H-indeno [5, 4-b] furan-6 (2H)-one and (+)- (S)-2-(hydroxymethyl)-7, 8-dihydro-1H-indeno [5, 4-b] furan-6 (2H)-one with high enantiomeric excess. Enantiomerically pure 2-(hydroxymethyl)-7, 8-dihydro-1H-indeno [5, ...