Organic letters

Simple synthesis of α-hydroxyamino carbonyl compounds: new scope of the nitroso aldol reaction

N Momiyama, H Yamamoto

Index: Momiyama, Norie; Yamamoto, Hisashi Organic Letters, 2002 , vol. 4, # 21 p. 3579 - 3582

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Citation Number: 94

Abstract

The reaction of nitroso compounds with enolates,” the nitroso aldol reaction”, occurs in high yield to generate α-hydroxyamino carbonyl compounds. Yields range from 42% to 98% with N-selectivity> 99: 1 from commercially available aromatic or aliphatic nitroso compounds and a variety of alkali metal or tin enolates.

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