Nickel (0) catalysed additions of hydrogen cyanide to alkynes: stereochemistry, mechanism, and preparative application

WR Jackson, CG Lovel

Index: Jackson, W. Roy; Lovel, Craig G. Journal of the Chemical Society, Chemical Communications, 1982 , # 21 p. 1231 - 1232

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Abstract

The addition of hydrogen cyanide to both terminal and disubstituted acetylenes occurs with cis- stereospecificity in moderate to excellent yields when catalysed by a nickel (0) complex. ... The addition of hydrogen cyanide to acetylene has been carried out on a large commercial scale using acid cata1ysis.l Copper based catalyst systems have also been used to promote this reaction.2 We report that the addition of hydrogen cyanide to sub- stituted acetylenes ...