Stereoselective synthesis of optically active cyclic α-and β-amino esters through lipase-catalyzed transesterification or interesterification processes

S Alatorre-Santamaría, V Gotor-Fernández…

Index: Alatorre-Santamaria, Sergio; Gotor-Fernandez, Vicente; Gotor, Vicente Tetrahedron Asymmetry, 2010 , vol. 21, # 18 p. 2307 - 2313

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Citation Number: 10

Abstract

A series of cyclic α-and β-amino esters belonging to a family of indolines and quinolines have been efficiently synthesized to study their behavior in lipase-mediated kinetic resolution reactions. The influence of the fused ring structure to the benzene ring and the position of the ester functionality relative to the amino group have been demonstrated, finding excellent values of enantiodiscrimination in the transesterification reaction of ...