Tetrahedron

Solid phase synthesis of guanidines

S Robinson, EJ Roskamp

Index: Robinson, Shaughnessy; Roskamp, Eric J. Tetrahedron, 1997 , vol. 53, # 19 p. 6697 - 6705

Full Text: HTML

Citation Number: 68

Abstract

A comparison of guanylating agents 1 and 2 was performed on a series of primary, secondary and aromatic amines in solution and on solid phase resins. Thiourea 1 performed well in solution and on solid supported primary and secondary amines. Pyrazole 2 performed well in each case, except one aniline which failed to react.

Related Articles:

Syntheses and inhibitory effects on gastric lesions of 4-guanidinomethylbenzoic acid arylamides.

[Ueda; Ikeda; Kakegawa; Miyataka; Matsumoto; Satoh Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 8 p. 1387 - 1390]

A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori

[Cheng, Ni; Xie, Jian-Shu; Zhang, Min-Yue; Shu, Chang; Zhu, De-Xu Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 16 p. 2703 - 2707]

More Articles...