Journal of medicinal chemistry

Potential antitumor agents. 21. Dialkanolamine dialkanesulfonic esters

BF Cain, WA Denny

Index: Cain,B.F.; Denny,W.A. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 515 - 520

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Citation Number: 12

Abstract

Homologous dialkanesulfonic esters of 2, 2'-iminodiethanol, 3, 3'-iminodi-l-propanol, N-(2- hydroxyethyl)-6-amino-1-hexanol, and N-(3-hydroxypropyl)-6-amino-l-hexanol were prepared via the N-trityl derivatives and screened for L1210 activity. For each active agent significant increases in life-span in L1210 tests (ILS) were correlated by linear least-squares regression with the corresponding log doses. The maximum ILS, taken from this ...