… and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1, 4-diazepin-6-yl) pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 …

…, H Harada, T Yoshikawa, N Yoshida…

Index: Hirokawa, Yoshimi; Fujiwara, Iwao; Suzuki, Kenji; Harada, Hiroshi; Yoshikawa, Takashi; Yoshida, Naoyuki; Kato, Shiro Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 702 - 715

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Citation Number: 30

Abstract

A structurally original series of N-(1-ethyl-4-methylhexahydro-1, 4-diazepin-6-yl) pyridine-3- carboxamides derived from the corresponding benzamide 5 were prepared and evaluated for their binding affinity for the dopamine D2 and serotonin 5-HT3 receptors using rat striatum and rat cortical membrane, respectively. Many of the synthesized pyridine-3- carboxamides exhibited nanomolar binding affinity for the serotonin 5-HT3 receptor along ...