Some α-Amino Acids Containing a Sulfonamide Group

DB Reisner

Index: Reisner Journal of the American Chemical Society, 1956 , vol. 78, p. 5102

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Citation Number: 10

Abstract

Conversion of homocystine hydantoin4 to 5-(p-chlorosulfony1)-ethylhydantoin was effected by chlorinating a suspension of the disulfide in water. Treatment of the sulfonyl chloride, suspended in ether, with ammonia or appropriate amine gave the desired sulfonamido- hydantoin. Subsequent hydrolysis of the hydantoin with aqueous barium hydroxide at approximately 160'afforded the corresponding amino acid (Table I). The synthesis of 3-(p- ...