Pyrrolo [4, 3, 2-de] isoquinolines with central nervous system and antihypertensive activities

CA Demerson, AH Philipp, LG Humber…

Index: Humber,L.G. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 1140 - 1145

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Citation Number: 10

Abstract

Chemistry. The first synthetic route to the pyrrolo [4, 3, 2-delisoquinoline system (Scheme I) involved an internal Mannich reaction of 4-aminomethylindole (1) 2 or 4- methylaminomethylindole (2) s with aliphatic or aromatic aldehydes to afford a series of 3- substituted and 3, 4-disubstituted 1, 3, 4, 5-tetrahydropyrrolo [4, 3, 2-de] isoquinolines