One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and SN Ar reaction

G Gellerman, V Gaisin, T Brider

Index: Gellerman, Gary; Gaisin, Vladimir; Brider, Tamara Tetrahedron Letters, 2010 , vol. 51, # 5 p. 836 - 839

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Citation Number: 12

Abstract

A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9- AA) at the amine position is described. Simple reductive amination and SNAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.