Synthesis and in vitro inhibitory activity on human platelet aggregation of novel properly substituted 4-(1-piperazinyl) coumarins

M Di Braccio, G Grossi, G Roma, MG Signorello…

Index: Di Braccio, Mario; Grossi, Giancarlo; Roma, Giorgio; Signorello, Maria Grazia; Leoncini, Giuliana European Journal of Medicinal Chemistry, 2004 , vol. 39, # 5 p. 397 - 409

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Citation Number: 23

Abstract

Pursuing our chemical and biological studies in this field, we described the multistep preparation of the new 5-, 6-, or 7-alkoxy and 7-alkoxy-8-methyl substituted 4-(1-piperazinyl) coumarins 5d-v, as well as the in vitro evaluation of their inhibitory activity on human platelet aggregation induced in platelet-rich plasma by ADP, collagen or the Ca2+ ionophore A23187. Compounds 5h-j, p, ru showed notably high activity towards all the platelet ...