Tetrahedron

Synthesis of the novel pyrimido [1, 6-a] pyrimidine and imidazo [1, 2-c] pyrimidine derivatives based on heterocyclic ketene aminals

A Alizadeh, J Mokhtari, M Ahmadi

Index: Alizadeh, Abdolali; Mokhtari, Javad; Ahmadi, Mehdi Tetrahedron, 2012 , vol. 68, # 1 p. 319 - 322

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Citation Number: 29

Abstract

A concise and efficient route for the synthesis of pyrimido [1, 6-a] pyrimidines and imidazo [1, 2-c] pyrimidines by simply refluxing a reaction mixture of different heterocyclic ketene aminals and N, N′-bis (arylmethylidene) arylmethane was developed. This protocol provides an alternative method for application in combinatorial and parallel synthesis in drug discovery.