Synthesis of Carboxyl??Tethered Symmetric Conjugated Polyenes as Fluorescent Transmembrane Probes of Lipid Bilayers

…, AU Acuña, F Amat??Guerri

Index: Quesada, Ernesto; Acuna, A. Ulises; Amat-Guerri, Francisco European Journal of Organic Chemistry, 2003 , # 7 p. 1308 - 1318

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Citation Number: 15

Abstract

Abstract The synthesis of a new series of fluorescent transmembrane probes in which two hydrophilic methyl ester or carboxyl groups are connected by a polymethylene chain, with four, five or six conjugated double bonds in a central position, is reported. The length of the linear structures was designed to match the width of typical lipid bilayers. These bolaamphiphilic compounds result, with overall yields higher than 80%, from an easy Pd II ...