Zirconocene-promoted coupling reaction of terminal acetylenes to geminal enediynes in the presence of p-chloranil

C Xi, Y Liu, X Yan, C Chen

Index: Xi, Chanjuan; Liu, Yuanyuan; Yan, Xiaoyu; Chen, Chao Journal of Organometallic Chemistry, 2007 , vol. 692, # 21 p. 4612 - 4617

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Citation Number: 10

Abstract

Reaction of alkynyllithium with zirconocene dichloride in the presence of quinones afforded zirconoenediynes in good yields. Treatment of the zirconoenediyne with p-chloranil in the presence of CuCl afforded 1, 1, 4, 4-tetraethynyl-1, 3-diene in good yield. In the presence of CuCl and/or Pd (PPh3) 4, the zirconoenediynes could be transformed into various enediyne derivatives through coupling reaction with electrophiles.