Design, synthesis and biological evaluation of novel anti-cytokine 1, 2, 4-triazine derivatives

…, R Miri, O Firuzi, A Madadkar-Sobhani, N Edraki…

Index: Khoshneviszadeh, Mehdi; Ghahremani, Mohammad H.; Foroumadi, Alireza; Miri, Ramin; Firuzi, Omidreza; Madadkar-Sobhani, Armin; Edraki, Najmeh; Parsa, Maliheh; Shafiee, Abbas Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6708 - 6717

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Citation Number: 16

Abstract

Abstract A series of 16 novel 1, 2, 4-triazine derivatives bearing hydrazone moiety (7a–7p) have been designed, synthesized and evaluated for their activity to inhibit IL-1β and TNF-α production. All compounds are reported for the first time. The chemical structures of all compounds were confirmed by spectroscopic methods and elemental analyzes. Most of the synthesized compounds were proved to have potent anti-cytokine activity and low toxicity ...