Multifaceted catalysis approach to nitrile activation: direct synthesis of halogenated allyl amides from allylic alcohols

RP Lester, JJ Dunsford, JE Camp

Index: Lester, Roy P.; Dunsford, Jay J.; Camp, Jason E. Organic and Biomolecular Chemistry, 2013 , vol. 11, # 43 p. 7472 - 7476

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Citation Number: 2

Abstract

Allyl amides were synthesised from the reaction of allyl alcohols and halogenated nitriles using a platinum multifaceted catalysis approach in which both the nucleophilic addition and subsequent [3, 3]-sigmatropic rearrangement steps of the process were catalysed by the same complex. Additionally, 1 H/13 C {1 H} NMR and GC studies provided the first insights into the mechanism of this transformation.