Chromophore-modified bis-benzo [g] indole carboxamides: synthesis and antiproliferative activity of bis-benzo [g] indazole-3-carboxamides and related dimers

…, JM Mussinu, G Murineddu, G Loriga, A Pau, GE Grella

Index: Pinna, Gerard A.; Pirisi, Maria A.; Mussinu, Jean-Mario; Murineddu, Gabriele; Loriga, Giovanni; Pau, Amedeo; Grella, Giuseppe E. Farmaco, 2003 , vol. 58, # 9 p. 749 - 763

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Citation Number: 24

Abstract

Tricyclic pyrazole dimers that comprise two kinds of CONH(CH2) n N (CH3)(CH2) n NHCO bridges to which are linked potential DNA-intercalating groups such as 1H-benzo [g] indazole, 2H-benzo [g] indazole and 1, 4-dihydroindeno [1, 2-c] pyrazole were designed, synthesized and some of them evaluated in vitro by NCI (Bethesda, USA) against nine types of cancer cells. Compounds 2a, 2f–i and 2o–r demonstrated significant antiproliferative ...