Molecules

Virtual screening and structure-based discovery of indole acylguanidines as potent β-secretase (BACE1) inhibitors

Y Zou, L Li, W Chen, T Chen, L Ma, X Wang, B Xiong…

Index: Zou, Yiquan; Li, Li; Chen, Wuyan; Chen, Tiantian; Ma, Lanping; Wang, Xin; Xiong, Bing; Xu, Yechun; Shen, Jingkang Molecules, 2013 , vol. 18, # 5 p. 5706 - 5722

Full Text: HTML

Citation Number: 9

Abstract

Abstract: Proteolytic cleavage of amyloid precursor protein by β-secretase (BACE1) is a key step in generating the N-terminal of β-amyloid (Aβ), which further forms into amyloid plaques that are considered as the hallmark of Alzheimer's disease. Inhibitors of BACE1 can reduce the levels of Aβ and thus have a therapeutic potential for treating the disease. We report here the identification of a series of small molecules bearing an indole acylguanidine core ...

Related Articles:

Formation of 4, 5, 6, 7-tetrahydroisoindoles by palladium-catalyzed hydride reduction

[Hou, Duen-Ren; Wang, Ming-Shiang; Chung, Ming-Wen; Hsieh, Yih-Dar; Tsai, Hui-Hsu Gavin Journal of Organic Chemistry, 2007 , vol. 72, # 24 p. 9231 - 9239]

The reaction of secondary α-amino acids with carbonyl compounds. Properties of the intermediate azomethine ylides. Oxazolidine formation versus 1.4-prototropy.

[Aly, Moustafa F.; Ardill, Harriet; Grigg, Ronald; Leong-Ling, Stephanie; Rajviroongit, Shuleewan; Surendrakumar, Sivagnanasundram Tetrahedron Letters, 1987 , vol. 28, # 48 p. 6077 - 6080]

Reactivity of a tetrahedral intermediate in hydrolysis of N??acetylpyrrole

[Cipiciani, Antonio; Savelli, Gianfranco; Bunton, Clifford A. Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 975 - 976]

More Articles...