Efficient Access to 1, 4-Benzothiazine: Palladium-Catalyzed Double C–S Bond Formation Using Na2S2O3 as Sulfurating Reagent∥

Z Qiao, H Liu, X Xiao, Y Fu, J Wei, Y Li, X Jiang

Index: Qiao, Zongjun; Liu, Hui; Xiao, Xiao; Fu, Yana; Wei, Jianpeng; Li, Yuxue; Jiang, Xuefeng Organic Letters, 2013 , vol. 15, # 11 p. 2594 - 2597

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Citation Number: 77

Abstract

A novel Pd-catalyzed double C–S bond formation coupling reaction has been developed. This protocol, in which Na2S2O3 was used as sulfurating reagent in metal-catalyzed reactions, provides an efficient method for the synthesis of substituted 1, 4-benzothiazine derivates, which are structural elements of numerous bioactivity molecules rendering this protocol attractive to both synthetic and medicinal chemistry.