Spiro heterocycles as potential inhibitors of SIRT1: Pd/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3, 2′-quinazolines

…, GPK Seerapu, KL Kumar, GS Deora, D Haldar…

Index: Rambabu; Raja, Guttikonda; Yogi Sreenivas; Seerapu; Lalith Kumar; Deora, Girdhar Singh; Haldar, Devyani; Rao, M.V.Basaveswara; Pal, Manojit Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1351 - 1357

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Citation Number: 14

Abstract

Novel N-indolylmethyl substituted spiroindoline-3, 2′-quinazolines were designed as potential inhibitiors of SIRT1. These compounds were synthesized in good yields by using Pd/C–Cu mediated coupling-cyclization strategy as a key step involving the reaction of 1- (prop-2-ynyl)-1′ H-spiro [indoline-3, 2′-quinazoline]-2, 4′(3′ H)-dione with 2- iodoanilides. Some of the compounds synthesized have shown encouraging inhibition of ...