Fast Reactivity of a Cyclic Nitrone− Calix [4] pyrrole Conjugate with Superoxide Radical Anion: Theoretical and Experimental Studies†

…, JL Zweier, A Rockenbauer, FA Villamena

Index: Kim, Shang-U; Liu, Yangping; Nash, Kevin M.; Zweier, Jay L.; Rockenbauer, Antal; Villamena, Frederick A. Journal of the American Chemical Society, 2010 , vol. 132, # 48 p. 17157 - 17173

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Citation Number: 25

Abstract

Nitrone spin traps have been employed as probes for the identification of transient radical species in chemical and biological systems using electron paramagnetic resonance (EPR) spectroscopy and have exhibited pharmacological activity against oxidative-stress-mediated diseases. Since superoxide radical anion (O2•−) is a major precursor to most reactive oxygen species and calix [4] pyrroles have been shown to exhibit high affinity to anions, a ...